By studying and tracking thousands of different molecules from people aged 25 to 75, researchers have identified two major waves of age-related changes, one at around 44 and another at 60.

Afghan Voice Agency (AVA): Scientists say that if you have noticed the sudden appearance of wrinkles, pain or a general feeling of aging almost overnight, this case may have a scientific explanation. Research shows that instead of being a slow, continuous process, aging occurs in at least two distinct time periods with a fast rhythm.

According to Euronews, by studying and tracking thousands of different molecules from people aged 25 to 75, researchers have identified two major waves of age-related changes, one at the age of 44 and the other at the age of 60.

"We don't just change gradually over time," says Professor Michael Snyder, a geneticist at Stanford University and senior author of the study. In fact, some changes occur suddenly and dramatically.

"The mid-40s, like the early 60s, seem to be a time of dramatic change, and that's true across the board, regardless of what class of molecules you're looking at," he added.

In this research, the researchers followed up laboratory samples of blood, feces, skin, and oral and nasal mucosa of 108 volunteers, which were sent to them every few months, for about 7 years.

They then analyzed 135,000 different RNA molecules (including proteins and metabolites) and microbes (including bacteria, viruses and fungi living in the gut and on the skin of the participants).

According to the researchers, the abundance of most molecules and microbes did not change significantly over time, and the transitions occurred when people were in their mid-40s and early 60s.

New findings of researchers: just 2 nights of lack of sleep can make you feel old

reversing the aging process; Scientists have increased the lifespan of beer yeast microbes by 80%.

In this regard, Dr. Snyder says: "The intensity of aging in the mid-40s was unexpected. It was initially thought that this was the result of premenopausal changes in women that would alter the results for the entire group. 

Dr. Xiaotao Shen, a researcher at Nanyang Technological University in Singapore and one of the authors of the study, also said: "This suggests that although menopause or pre-menopause may play a role in the changes observed in women in their mid-40s, "Probably other important factors also influence these changes in men and women."

Researchers say that the signs of aging appear in two distinct periods during life.

The first wave of changes included molecules related to cardiovascular diseases and the ability to metabolize caffeine, alcohol and lipids. The second wave of changes included molecules involved in immune regulation, carbohydrate metabolism and kidney function.

Molecules associated with skin and muscle aging changed at both times, scientists say.

Previous research has shown that aging can occur as early as age 78, although the new study could not confirm this because the oldest participants were 75 years old.

This pattern is consistent with previous evidence that the risk of many diseases associated with aging does not increase gradually, but rather occurs in spurts and with high intensity. Such as the risk of Alzheimer's and cardiovascular diseases, which show a sharp increase after the age of 60.

Changes in alcohol metabolism can also be caused by increased consumption in the mid-40s of people facing a stressful period of life.

According to the authors, increasing exercise and physical activity during periods of faster muscle loss can help combat aging during these critical time periods.

"I believe that we should try to adjust our lifestyle while we are still healthy," says Dr. Snyder.